The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

J Korbecki, K Bajdak-Rusinek - Inflammation Research, 2019 - Springer
Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …

Dyslipidemia in obesity: mechanisms and potential targets

B Klop, JWF Elte, M Castro Cabezas - Nutrients, 2013 - mdpi.com
Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

E Thijssen, A Van Caam, PM Van Der Kraan - Rheumatology, 2015 - academic.oup.com
OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Metabolic syndrome and the lung

CW Baffi, L Wood, D Winnica, PJ Strollo Jr, MT Gladwin… - Chest, 2016 - Elsevier
A link between metabolic syndrome (MetS) and lung diseases has been observed in several
cross-sectional and longitudinal studies. This syndrome has been identified as an …

[HTML][HTML] Palmitate activates the NF-κB transcription factor and induces IL-6 and TNFα expression in 3T3-L1 adipocytes

KM Ajuwon, ME Spurlock - The Journal of nutrition, 2005 - Elsevier
Fatty acids and their metabolites regulate gene expression and immunological pathways.
Furthermore, obese individuals frequently have increased circulating fatty acid …

[HTML][HTML] Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes

HK Kim, MA Della-Fera, J Lin, CA Baile - The Journal of nutrition, 2006 - Elsevier
ABSTRACT Docosahexaenoic acid (DHA, C22: 6), a (n-3) fatty acid in fish oil, has been
shown to decrease body fat and fat accumulation in rodents. We investigated the direct effect …

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

LG Wood, Q Li, HA Scott, S Rutting, BS Berthon… - Journal of Allergy and …, 2019 - Elsevier
Background Both obesity and high dietary fat intake activate the nucleotide oligomerization
domain–like receptor protein 3 (NLRP3) inflammasome. Objective We aimed to examine …

Obstructive sleep apnea dynamically increases nocturnal plasma free fatty acids, glucose, and cortisol during sleep

S Chopra, A Rathore, H Younas… - The Journal of …, 2017 - academic.oup.com
Context Obstructive sleep apnea (OSA) is associated with diabetes and cardiovascular
disease. This association may be related to metabolic changes that transpire during sleep in …

Mangiferin Improved Palmitate‐Induced‐Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPARα: Mangiferin Improved …

Q Zhang, X Kong, H Yuan, H Guan… - Journal of Diabetes …, 2019 - Wiley Online Library
Elevated free fatty acid (FFA) is a key risk factor for insulin resistance (IR). Our previous
studies found that mangiferin could decrease serum FFA levels in obese rats induced by a …

The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis

Q Ling, J Chen, X Liu, Y Xu, J Ma, P Yu… - Frontiers in …, 2023 - frontiersin.org
Background The triglyceride and glucose (TyG) index is associated with the risk of
nonalcoholic fatty liver disease (NAFLD), but the dose− response relationship between them …