Evolution of the innate immune system: the worm perspective

H Schulenburg, C Léopold Kurz… - Immunological …, 2004 - Wiley Online Library
Simple model organisms that are amenable to comprehensive experimental analysis can be
used to elucidate the molecular genetic architecture of complex traits. They can thereby …

'Ready made'virulence and 'dual use'virulence factors in pathogenic environmental fungi—the Cryptococcus neoformans paradigm

A Casadevall, JN Steenbergen… - Current Opinion in …, 2003 - Elsevier
Environmental pathogenic fungi present a paradox in that they are virulent in animals
without requiring animal hosts for replication or survival, a phenomenon we call 'ready …

Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans

C Portal-Celhay, ER Bradley, MJ Blaser - BMC microbiology, 2012 - Springer
Background A powerful approach to understanding complex processes such as aging is to
use model organisms amenable to genetic manipulation, and to seek relevant phenotypes …

Evaluation of probiotic characteristics of newly isolated Lactobacillus spp.: immune modulation and longevity

J Lee, HS Yun, KW Cho, S Oh, SH Kim, T Chun… - International journal of …, 2011 - Elsevier
In the current study, the probiotic potential of approximately 350 strains of lactic acid bacteria
isolated from Korean infant feces and Kimchi was investigated. Common probiotic properties …

Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps?

P Van Baarlen, A Van Belkum… - FEMS microbiology …, 2007 - academic.oup.com
It is common knowledge that pathogenic viruses can change hosts, with avian influenza, the
HIV, and the causal agent of variant Creutzfeldt–Jacob encephalitis as well-known …

Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts

TA Missall, JK Lodge, JE McEwen - Eukaryotic cell, 2004 - Am Soc Microbiol
The ability of a fungal pathogen to cause disease requires the ability to survive in the host.
Survival in the host is dependent on evasion of the host's immune system, including the …

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens

JR Powell, FM Ausubel - Innate immunity, 2008 - Springer
The nematode Caenorhabditis elegans is a simple model host for studying the relationship
between the animal innate immune system and a variety of bacterial and fungal pathogens …

Antifungal Efficacy during Candida krusei Infection in Non-Conventional Models Correlates with the Yeast In Vitro Susceptibility Profile

L Scorzoni, MP de Lucas, AC Mesa-Arango… - PloS one, 2013 - journals.plos.org
The incidence of opportunistic fungal infections has increased in recent decades due to the
growing proportion of immunocompromised patients in our society. Candida krusei has …

[HTML][HTML] The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans

JN Steenbergen, A Casadevall - Microbes and infection, 2003 - Elsevier
The origin of virulence in environmental fungi that have no requirement for animal hosts in
their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with …

[HTML][HTML] Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans

H Schulenburg, MP Hoeppner, J Weiner III… - Immunobiology, 2008 - Elsevier
The nematode Caenorhabditis elegans has become an important model for the study of
innate immunity. Its immune system is based on several signaling cascades, including a Toll …