Strategies for engineering of extracellular vesicles

AA Danilushkina, CC Emene, NA Barlev… - International journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released by cells into the extracellular
space. EVs mediate cell-to-cell communication through local and systemic transportation of …

Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications

Y Xue, N Riva, L Zhao, J Shieh, YT Chin, A Gatt… - Journal of Controlled …, 2023 - Elsevier
Sports medicine is generally associated with soft tissue injuries including muscle injuries,
meniscus and ligament injuries, tendon ruptures, tendinopathy, rotator cuff tears, and tendon …

Forging new therapeutic targets: efforts of tumor derived exosomes to prepare the pre-metastatic niche for cancer cell dissemination and dormancy

R Bhatia, J Chang, JL Munoz, ND Walker - Biomedicines, 2023 - mdpi.com
Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche,
promoting cancer dissemination, and regulating cancer cell dormancy. A brief review of …

Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury

A Tieu, DJ Stewart, D Chwastek, C Lansdell… - Stem Cell Research & …, 2023 - Springer
Background Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a
promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated …

Cellular Uptake of Engineered Extracellular Vesicles: Biomechanisms, Engineered Strategies, and Disease Treatment

Q Xie, Y Hao, N Li, H Song, X Chen… - Advanced …, 2024 - Wiley Online Library
Abstract Extracellular vesicles (EVs), lipid‐enclosed nanosized membrane vesicles, are
regarded as new vehicles and therapeutic agents in intercellular communication. During …

Extracellular vesicles as reconfigurable therapeutics for eye diseases: Promises and hurdles

F Shekari, M Abyadeh, A Meyfour, M Mirzaei… - Progress in …, 2023 - Elsevier
A large number of people worldwide suffer from visual impairment. However, most available
therapies rely on impeding the development of a particular eye disorder. Therefore, there is …

Formation and Investigation of Cell‐Derived Nanovesicles as Potential Therapeutics against Chronic Liver Disease

AA Ganguin, I Skorup, S Streb… - Advanced healthcare …, 2023 - Wiley Online Library
A new therapeutic approach using cell‐derived nanovesicles (cdNVs) is offered here to
overcome the lack of effective treatments for liver fibrosis, a reversible chronic liver disease …

Extracellular vesicles as human therapeutics: A scoping review of the literature

C Fusco, G De Rosa, I Spatocco… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are released by all cells and contribute to cell‐to‐cell
communication. The capacity of EVs to target specific cells and to efficiently deliver a …

Biological functions and biomedical applications of extracellular vesicles derived from blood cells

K Pan, Y Zhu, P Chen, K Yang, Y Chen, Y Wang… - Free Radical Biology …, 2024 - Elsevier
There is a growing interest in using extracellular vesicles (EVs) for therapeutic applications.
EVs are composed of cytoplasmic proteins and nucleic acids and an external lipid bilayer …

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

D Wu, X Zhao, J Xie, R Yuan, Y Li, Q Yang… - Cell …, 2024 - Wiley Online Library
Mesenchymal stem cell‐derived exosomes (MSC‐Exo) offer promising therapeutic potential
for various refractory diseases, presenting a novel therapeutic strategy. However, their …