[HTML][HTML] Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function
K Liu, R Nilsson, E Lázaro-Ibáñez, H Duàn… - Nature …, 2023 - nature.com
In terms of lipid nanoparticle (LNP) engineering, the relationship between particle
composition, delivery efficacy, and the composition of the biocoronas that form around LNPs …
composition, delivery efficacy, and the composition of the biocoronas that form around LNPs …
[HTML][HTML] Advances in the delivery of RNA therapeutics: from concept to clinical reality
The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …
people around the globe and are a major public health burden. Most contemporary …
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
S Yonezawa, H Koide, T Asai - Advanced drug delivery reviews, 2020 - Elsevier
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery
systems, which have limitations for clinical applications. Translational efforts to develop …
systems, which have limitations for clinical applications. Translational efforts to develop …
Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy
The induction of a strong cytotoxic T cell response is an important prerequisite for successful
immunotherapy against many viral diseases and tumors. Nucleotide vaccines, including …
immunotherapy against many viral diseases and tumors. Nucleotide vaccines, including …
Emerging frontiers in drug delivery
Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …
[HTML][HTML] Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
Lipid-like nanoparticles (LNPs) have potential as non-viral delivery systems for mRNA
therapies. However, repeated administrations of LNPs may lead to accumulation of delivery …
therapies. However, repeated administrations of LNPs may lead to accumulation of delivery …
[HTML][HTML] RNA circularization diminishes immunogenicity and can extend translation duration in vivo
RA Wesselhoeft, PS Kowalski, FC Parker-Hale… - Molecular cell, 2019 - cell.com
Circular RNAs (circRNAs) are a class of single-stranded RNAs with a contiguous structure
that have enhanced stability and a lack of end motifs necessary for interaction with various …
that have enhanced stability and a lack of end motifs necessary for interaction with various …
mRNA vaccine delivery using lipid nanoparticles
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …