[HTML][HTML] mRNA vaccine for cancer immunotherapy
Abstract mRNA vaccines have become a promising platform for cancer immunotherapy.
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …
Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs
KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein… - Nano …, 2015 - ACS Publications
Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein
production for many therapeutic applications. Although lipid nanoparticles have shown …
production for many therapeutic applications. Although lipid nanoparticles have shown …
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
Stereochemistry can alter small-molecule pharmacokinetics, safety and efficacy. However, it
is unclear whether the stereochemistry of a single compound within a multicomponent …
is unclear whether the stereochemistry of a single compound within a multicomponent …
Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications
Lipid nanoparticles (LNPs) have proven a successful platform for the delivery of nucleic acid
(NA)‐based therapeutics and vaccines, with the ionizable lipid component playing a key role …
(NA)‐based therapeutics and vaccines, with the ionizable lipid component playing a key role …
Enzyme-catalyzed one-step synthesis of ionizable cationic lipids for lipid nanoparticle-based mRNA COVID-19 vaccines
Ionizable cationic lipid-containing lipid nanoparticles (LNPs) are the most clinically
advanced non-viral gene delivery platforms, holding great potential for gene therapeutics …
advanced non-viral gene delivery platforms, holding great potential for gene therapeutics …
Iterative design of ionizable lipids for intramuscular mRNA delivery
G Tilstra, J Couture-Senécal, YMA Lau… - Journal of the …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and
have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines …
have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines …
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver
R Zhang, R El-Mayta, TJ Murdoch, CC Warzecha… - Biomaterials …, 2021 - pubs.rsc.org
Nucleic acids, such as messenger RNAs, antisense oligonucleotides, and short interfering
RNAs, hold great promise for treating previously 'undruggable'diseases. However, there are …
RNAs, hold great promise for treating previously 'undruggable'diseases. However, there are …
The importance of apparent pKa in the development of nanoparticles encapsulating siRNA and mRNA
P Patel, NM Ibrahim, K Cheng - Trends in pharmacological sciences, 2021 - cell.com
Polymer and lipid nanoparticles have been extensively used as carriers to address the
biological barriers encountered in siRNA and mRNA delivery. We summarize the crucial role …
biological barriers encountered in siRNA and mRNA delivery. We summarize the crucial role …
Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
S Guan, J Rosenecker - Gene therapy, 2017 - nature.com
Because of its safe and effective protein expression profile, in vitro transcribed messenger
RNA (IVT-mRNA) represents a promising candidate in the development of novel …
RNA (IVT-mRNA) represents a promising candidate in the development of novel …
Recent progress in development of siRNA delivery vehicles for cancer therapy
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …