Lipid-based nanoparticle formulations for small molecules and RNA drugs
LM Ickenstein, P Garidel - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Liposomes and lipid-based nanoparticles (LNPs) effectively deliver cargo
molecules to specific tissues, cells, and cellular compartments. Patients benefit from these …
molecules to specific tissues, cells, and cellular compartments. Patients benefit from these …
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
JE Dahlman, KJ Kauffman, Y Xing… - Proceedings of the …, 2017 - National Acad Sciences
Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by
an incomplete understanding of how nanoparticle structure affects biodistribution to off …
an incomplete understanding of how nanoparticle structure affects biodistribution to off …
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
PPG Guimaraes, R Zhang, R Spektor, M Tan… - Journal of Controlled …, 2019 - Elsevier
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …
with the potential to induce protein production to treat and prevent a range of diseases …
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
CD Sago, MP Lokugamage, D Loughrey… - Nature biomedical …, 2022 - nature.com
Systemically delivered lipid nanoparticles are preferentially taken up by hepatocytes. This
hinders the development of effective, non-viral means of editing genes in tissues other than …
hinders the development of effective, non-viral means of editing genes in tissues other than …
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
M Krohn-Grimberghe, MJ Mitchell, MJ Schloss… - Nature biomedical …, 2020 - nature.com
Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of
blood vessels that regulates blood-cell traffic as well as the maintenance and function of …
blood vessels that regulates blood-cell traffic as well as the maintenance and function of …
Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells
mRNA therapeutics hold great potential for treating a variety of diseases through protein-
replacement, immunomodulation, and gene editing. However, much like siRNA therapy the …
replacement, immunomodulation, and gene editing. However, much like siRNA therapy the …
Accelerating the translation of nanomaterials in biomedicine
Due to their size and tailorable physicochemical properties, nanomaterials are an emerging
class of structures utilized in biomedical applications. There are now many prominent …
class of structures utilized in biomedical applications. There are now many prominent …
Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA
Intracellular delivery of mRNA holds great potential for vaccine1− 3 and therapeutic4
discovery and development. Despite increasing recognition of the utility of lipid-based …
discovery and development. Despite increasing recognition of the utility of lipid-based …
mRNA delivery for therapeutic anti-HER2 antibody expression in vivo
Antibody-based drugs are a leading class of biologics used to treat a variety of diseases,
including cancer. However, wide antibody implementation is hindered by manufacturing …
including cancer. However, wide antibody implementation is hindered by manufacturing …
[HTML][HTML] Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors
K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic
cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new …
cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new …