K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic
cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new …

Smart biomaterials have the ability to respond to changes in physiological parameters and
exogenous stimuli and continue to impact many aspects of modern medicine. Smart …

Using mRNA to produce therapeutic proteins is a promising approach to treat genetic
diseases. However, systemically delivering mRNA to cell types besides hepatocytes …

Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

Abstract Treatment and management of kidney disease currently presents an enormous
global burden, and the application of nanotechnology principles to renal disease therapy …

Endothelial cells and macrophages play active roles in disease and as a result are important
targets for nucleic acid therapies. While thousands of chemically distinct lipid nanoparticles …

Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical
and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed …

RNA-based therapeutics have shown great promise in various medical applications,
including cancers, infectious diseases, and metabolic diseases. The recent success of …

Abstract mRNA is a versatile drug molecule with therapeutic applications ranging from
protein replacement therapies to in vivo gene engineering. mRNA delivery is often …