Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …

RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …

(Figure 1a). Taking advantage of the high cytosolic esterase activity in HeLa cancer cells but
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …

Macropinocytosis is a means by which eukaryotic cells ingest extracellular liquid and
dissolved molecules. It is widely conserved amongst cells that can take on amoeboid form …

Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic
applications in the past few years. A series of clinical trials are ongoing or will be initiated in …

Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and
humans, resulting in secondary ischemic complications and high mortality. We show that, in …

Lipid-based nanoparticles (LNPs) for the delivery of mRNA have jumped to the forefront of
non-viral gene delivery. Despite this exciting development, poor endosomal escape after …

Lipid nanoparticles (LNPs) are one of the more promising technologies for efficiently
delivering short interfering RNA (siRNA) in vivo. A pH-sensitive cationic lipid that facilitates …

Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

The clinical translation of messengerRNA (mRNA) drugs has been slowed by a shortage of
delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe …