Nanoparticle‐mediated delivery of Anti‐PU. 1 siRNA via localized intracisternal administration reduces neuroinflammation
WT Ralvenius, JL Andresen, MM Huston… - Advanced …, 2024 - Wiley Online Library
Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's
disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified …
disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified …
Delivery of oligonucleotides with lipid nanoparticles
Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have
been recognized as powerful tools that can treat a broad spectrum of diseases. The …
been recognized as powerful tools that can treat a broad spectrum of diseases. The …
[HTML][HTML] Understanding structure activity relationships of Good HEPES lipids for lipid nanoparticle mRNA vaccine applications
RL Goldman, NTV Murthy, TP Northen, A Balakrishnan… - Biomaterials, 2023 - Elsevier
Lipid nanoparticles (LNPs) have shown great promise as delivery vehicles to transport
messenger ribonucleic acid (mRNA) into cells and act as vaccines for infectious diseases …
messenger ribonucleic acid (mRNA) into cells and act as vaccines for infectious diseases …
Dynamic carriers for therapeutic RNA delivery
Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA
during delivery to the target tissue and across cellular membrane barriers and then …
during delivery to the target tissue and across cellular membrane barriers and then …
Harnessing Topology and Stereochemistry of Glycidylamine‐Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application …
MM Abd Elwakil, R Suzuki, AM Khalifa… - Advanced Functional …, 2023 - Wiley Online Library
Abstract mRNA lipid nanoparticles (LNPs) have reached an inflection point and are now
paving the way for a new wave of precision therapies. The design of nonhepatocyte RNA …
paving the way for a new wave of precision therapies. The design of nonhepatocyte RNA …
RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
mRNA therapeutics are promising platforms for protein replacement therapies and gene
editing technologies. When delivered via non-viral gene delivery systems, such as lipid …
editing technologies. When delivered via non-viral gene delivery systems, such as lipid …
[HTML][HTML] Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
B Hu, B Li, K Li, Y Liu, C Li, L Zheng, M Zhang… - Science …, 2022 - science.org
Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the
treatment of hyperlipidemia. Establishment of a thermostable clinically applicable delivery …
treatment of hyperlipidemia. Establishment of a thermostable clinically applicable delivery …
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However,
cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are …
cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are …