Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

An update is available for this article. Description: The purpose of this guideline from the
American College of Physicians (ACP) is to present updated clinical recommendations on …

Background Variation within the CYP2C19 gene has been linked to differential metabolism
of selective serotonin reuptake inhibitors (SSRIs). Pharmacogenetic recommendations …

Mood disorders can be considered among the most common and debilitating mental
disorders. Major depression, as an example of mood disorders, is known to severely reduce …

An update is available for this article. Background: Primary care patients and clinicians may
prefer alternative options to second-generation antidepressants for major depressive …

Objective To compare effectiveness of onabotulinumtoxinA and topiramate for chronic
migraine (CM) prevention. Background The efficacy* of onabotulinumtoxinA and topiramate …

Major depressive disorder (MDD) is a common psychiatric illness that manifests in sex-
influenced ways. Men and women may experience depression differently and also respond …

The clinical guidelines that underpin the use of drugs for mental disorders are informed by
evidence from randomised controlled trials (RCTs). RCTs are performed to obtain marketing …