Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …

Background: Immune checkpoint inhibitors (ICIs) have shown encouraging treatment
efficacy for metastatic breast cancer in several clinical trials. However, response only …

ABSTRACT Background and Aims: As the predominant lymphocyte subset in the liver,
natural killer (NK) cells have been shown to be highly associated with the outcomes of …

Natural killer (NK) cells are enriched within the liver. Apart from conventional NK (cNK) cells,
recent studies identified a liver-resident NK (LrNK) subset, which constitutes about half of …

Natural killer (NK) cells are potential effector cells in cell-based cancer immunotherapy,
particularly in the control of hematological malignancies. The chimeric antigen receptor …

Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

The liver represents a frontline immune organ that is constantly exposed to a variety of gut-
derived antigens as a result of its unique location and blood supply. With a predominant role …

Innate sensing of pathogens by pattern-recognition receptors (PRRs) plays essential roles in
the innate discrimination between self and non-self components, leading to the generation …

Liver cancer is one of the most common malignancies, and various pathogenic factors can
lead to its occurrence and development. Among all primary liver cancers, hepatocellular …