[HTML][HTML] Suppression of natural killer cell activity by regulatory NKT10 cells aggravates alcoholic hepatosteatosis

K Cui, G Yan, X Zheng, L Bai, H Wei, R Sun… - Frontiers in …, 2017 - frontiersin.org
We and others have found that the functions of hepatic natural killer (NK) cells are inhibited
but invariant NKT (iNKT) cells become activated after alcohol drinking, leaving a possibility …

[HTML][HTML] Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: Current knowledge and future perspectives

N Jacquelot, C Seillet… - International Journal of …, 2021 - mdpi.com
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid
cell subsets that are key for the detection and elimination of pathogens and cancer cells. In …

[HTML][HTML] Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver

L Liu, B Dai, R Li, Z Liu, Z Zhang - Theranostics, 2021 - ncbi.nlm.nih.gov
Cytotoxic T lymphocytes (CTLs) and their gene-engineered cells display great application
prospects in tumor immunotherapy. The timing of CTL-induced molecular events in tumor …

[HTML][HTML] Role of exosomes in immunotherapy of hepatocellular carcinoma

BW Tian, CL Han, ZR Dong, SY Tan, DX Wang, T Li - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma is one of the most lethal malignancies, having a
significantly poor prognosis. Immunotherapy, as an emerging tumor treatment option …

[HTML][HTML] miR-302a inhibits human HepG2 and SMMC-7721 cells proliferation and promotes apoptosis by targeting MAP3K2 and PBX3

M Wang, G Lv, C Jiang, S Xie, G Wang - Scientific Reports, 2019 - nature.com
Hepatocellular carcinoma (HCC) is the most common liver cancer and has a poor prognosis.
miR-302a is an important regulator of tumor occurrence and deterioration, while MAP3K2 …

Involvement of NK cells in IL-28B–mediated immunity against influenza virus infection

Y Wang, T Li, Y Chen, H Wei, R Sun… - The Journal of …, 2017 - journals.aai.org
IL-28B is a member of the newly discovered type III IFN family and exhibits unique antiviral
properties compared with other family members. NK cells play a critical role in defending …

Nanomedicines for reversing immunosuppressive microenvironment of hepatocellular carcinoma

X Pan, S Ni, K Hu - Biomaterials, 2024 - Elsevier
Although immunotherapeutic strategies such as immune checkpoint inhibitors (ICIs) have
gained promising advances, their limited efficacy and significant toxicity remain great …

Natural killer cells: functional differences in recurrent spontaneous abortion

F Hao, X Zhou, L Jin - Biology of Reproduction, 2020 - academic.oup.com
Recurrent spontaneous abortion (RSA) is one of the major pregnancy disorders and poses a
serious risk to both the mother and the fetus. Although a number of research efforts have …

A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity

G Kang, X Zhao, J Sun, C Cheng, C Wang… - International …, 2023 - Elsevier
CD39-mediated inhibition of natural killer (NK) cell activity has been demonstrated, but the
characteristics of CD39+ NK cells in humans are not known. We investigated the …

IL‐21 collaborates with anti‐TIGIT to restore NK cell function in chronic HBV infection

L Tang, Q Li, L Chen, X Li, S Gu, W He… - Journal of Medical …, 2023 - Wiley Online Library
Available therapies for chronic hepatitis B virus (HBV) infection are not satisfying, and
interleukin‐21 (IL‐21) and checkpoint inhibitors are potential therapeutic options. However …