Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
[PDF][PDF] Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
[HTML][HTML] Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness
MA Calcia, DR Bonsall, PS Bloomfield, S Selvaraj… - …, 2016 - Springer
Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …
Glia and pain: is chronic pain a gliopathy?
Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice
F Guida, F Turco, M Iannotta, D De Gregorio… - Brain, behavior, and …, 2018 - Elsevier
The microbiota-gut-brain axis (MGBA) regulates the reciprocal interaction between chronic
inflammatory bowel and psychiatric disorders. This interaction involves multiple pathways …
inflammatory bowel and psychiatric disorders. This interaction involves multiple pathways …
Minocycline: far beyond an antibiotic
N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …
use for over 30 years because of its antibiotic properties against both gram‐positive and …
Evidence for brain glial activation in chronic pain patients
Although substantial evidence has established that microglia and astrocytes play a key role
in the establishment and maintenance of persistent pain in animal models, the role of glial …
in the establishment and maintenance of persistent pain in animal models, the role of glial …
Post-traumatic headache: epidemiology and pathophysiological insights
Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one
of the most common sequelae of mild traumatic brain injury, also known as concussion …
of the most common sequelae of mild traumatic brain injury, also known as concussion …
Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord
Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in
spinal microglia participates in the generation of inflammatory and neuropathic pain in …
spinal microglia participates in the generation of inflammatory and neuropathic pain in …