Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in
development of chronic inflammatory disorders and the inflamed tumor microenvironment …

Background Immunotherapeutic approaches, including immune checkpoint inhibitor (ICI)
therapy, are increasingly recognized for their potential. Despite notable successes, patient …

During cancer evolution, tumor cells attract and dynamically interact with monocytes/
macrophages. To find biomarkers of disease progression in human melanoma, we used …

Previously, we showed that 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD), an aryl
hydrocarbon receptor (AhR) ligand and a potent and persistent toxicant and carcinogenic …

Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to
induce tumor-specific T cell responses and enhance therapeutic outcomes. However …

Severe immunosuppression is a hallmark of colorectal cancer (CRC). Myeloid-derived
suppressor cells (MDSCs), one of the most abundant components of the tumor stroma, play …

Melanoma is the leading cause of global skin cancer-related death and currently ranks as
the third most commonly diagnosed cancer in Australia. Melanoma patients with in-transit …

This study investigates the role of Stanniocalcin-1 (STC1) in melanoma progression, with a
focus on its impact on metastasis, angiogenesis, and immune evasion. Systematic …

Metastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates.
Despite the clinical success of recent immunotherapy approaches, prevailing resistance …