Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

Hyperbaric oxygen treatment (HBOT)—the medical use of oxygen at environmental pressure
greater than one atmosphere absolute—is a very effective therapy for several approved …

Systemic inflammation often induces neuroinflammation and disrupts neural functions,
ultimately causing cognitive impairment. Furthermore, neuronal inflammation is the key …

Delayed neurocognitive recovery (dNCR) is a prevalent perioperative neurological
complication in older patients and has common characteristics such as acute cognitive …

For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of
indications involving tissue repair. These indications comprise a wide range of diseases …

Ischemic stroke (IS) has become the second leading cause of morbidity and mortality
worldwide, and the prevention of IS should be given high priority. Recent studies have …

Objectives Clinically, there is no effective therapy for postoperative cognitive dysfunction
(POCD). Inflammation after surgery is closely associated with POCD. Methods In this study …

We recently reported that isoflurane conditioning provided multifaceted protection against
subarachnoid hemorrhage (SAH)-induced delayed cerebral ischemia (DCI), and this …

Objectives: Elderly patients often suffer from cognitive dysfunction following surgery.
However, the mechanisms underlying this phenomenon still remain unclear. This study …

Diabetes-associated cognitive dysfunction (DACD) characterized by hippocampal injury
increases the risk of major cerebrovascular events and death. Endoplasmic reticulum (ER) …