The World Health Organization (WHO) refers to obesity as abnormal or excessive fat
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …

Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

There is strong evidence indicating that excess adiposity negatively impacts immune
function and host defence in obese individuals. This is a review of research findings …

Purpose To provide recommendations for appropriate cytotoxic chemotherapy dosing for
obese adult patients with cancer. Methods The American Society of Clinical Oncology …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in
the (extreme) overweight population. Obesity has a great impact on key organs that play a …

The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho) physiological alterations associated with obesity have been …

Guidelines are presented for the organisational and clinical peri‐operative management of
anaesthesia and surgery for patients who are obese, along with a summary of the problems …