[HTML][HTML] Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

[HTML][HTML] Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications

AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …

Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection

NS Sharif-Askari, FS Sharif-Askari, B Mdkhana… - Free Radical Biology …, 2021 - Elsevier
Severe viral infections, including SARS-COV-2, could trigger disruption of the balance
between pro-oxidant and antioxidant mediators; the magnitude of which could reflect the …

Total antioxidant capacity as a marker of severity of COVID‐19 infection: Possible prognostic and therapeutic clinical application

N Yaghoubi, M Youssefi, F Jabbari Azad… - Journal of medical …, 2022 - Wiley Online Library
The pathogenesis of SARS‐CoV‐2 infection, causative pathogen of the known COVID‐19
pandemic is not well clarified. In this regard oxidative stress is one of the topics that need to …

[HTML][HTML] The impact of severe COVID-19 on plasma antioxidants

N Žarković, A Jastrząb, I Jarocka-Karpowicz… - Molecules, 2022 - mdpi.com
Several studies suggested the association of COVID-19 with systemic oxidative stress, in
particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate …

[HTML][HTML] Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

[HTML][HTML] Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

I Al-Saleh, N Alrushud, H Alnuwaysir, R Elkhatib… - Biometals, 2022 - Springer
The role of micronutrient deficiency in the pathogenesis of COVID-19 has been reviewed in
the literature; however, the data are limited and conflicting. This study investigated the …

Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels

J Lou, H Zhang, J Qi, Y Xu, X Wang… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Necrosis of random‐pattern skin flaps limits their clinical
application. Helix B surface peptide (HBSP) protects tissues from ischaemia–reperfusion …

Mitochondrial dysfunction: a prelude to neuropathogenesis of SARS-CoV-2

A Pliss, AN Kuzmin, PN Prasad… - ACS chemical …, 2022 - ACS Publications
The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple
neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to …