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Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of
patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived …

Objectives: We sought to determine whether there was a relationship between serum
digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy …

Because of the common use of digoxin and because of its narrow therapeutic index, digoxin
toxicity has been prevalent historically and, therefore, most clinicians are well aware of the …

Probenecid is a highly lipid soluble benzoic acid derivative originally used to increase
serum antibiotic concentrations. It was later discovered to have uricosuric effects and was …

Methods Digoxin users were identified in the Rotterdam Study, a prospective population-
based cohort study of individuals aged 55 years and above. Digoxin blood levels were …

OBJECTIVE: To evaluate the relationship of the therapeutic serum digoxin concentration
(SDC) range (0.5–2 ng/mL, as recommended in previous clinical studies) with the incidence …

Background: The safety of digoxin (digitalis) therapy has greatly improved over the past
three decades, but recent incidence rates for digoxin intoxication-related hospitalisation are …

BACKGROUND: The advent of medical therapies for congestive heart failure that have
proven survival benefits, specifically angiotensin-converting enzyme (ACE) inhibitors, β …

We hypothesized that digoxin toxicity has declined in recent years, and that the decline is
accompanied by reductions in overall utilization and dose. To analyze trends in digoxin …