Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost
MM El Tabaa, MM El Tabaa - Biochemical Pharmacology, 2020 - Elsevier
COVID-19 is an ongoing viral pandemic disease that is caused by SARS-CoV2, inducing
severe pneumonia in humans. However, several classes of repurposed drugs have been …
severe pneumonia in humans. However, several classes of repurposed drugs have been …
Protective renal effects of atrial natriuretic peptide: where are we now?
MR Choi, BE Fernández - Frontiers in Physiology, 2021 - frontiersin.org
Atrial natriuretic peptide belongs to the family of natriuretic peptides, a system with
natriuretic, diuretic, and vasodilator effects that opposes to renin-angiotensin system. In …
natriuretic, diuretic, and vasodilator effects that opposes to renin-angiotensin system. In …
Sacubitril/valsartan reduces susceptibility to atrial fibrillation by improving atrial remodeling in spontaneously hypertensive rats
Q Li, Y Fang, D Peng, L Li, C Deng, H Yang… - European Journal of …, 2023 - Elsevier
Abstract Aim Sacubitril/valsartan (Sac/Val, LCZ696), the world's first angiotensin receptor-
neprilysin inhibitor (ARNi), has been widely used in the treatment of heart failure. However …
neprilysin inhibitor (ARNi), has been widely used in the treatment of heart failure. However …
The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction
J Ding, S Cui, SY Li, LY Cui, QY Nan, XJ Lin, MY Xuan… - Plos one, 2023 - journals.plos.org
The angiotensin receptor neprilysin inhibitor LCZ696 affords superior cardioprotection and
renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying …
renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying …
Cardiovascular and renal outcomes of mineralocorticoid receptor antagonist use in PARAGON-HF
Objectives This study sought to evaluate the efficacy and safety of sacubitril/valsartan in
patients with heart failure with preserved ejection fraction (HFpEF) according to background …
patients with heart failure with preserved ejection fraction (HFpEF) according to background …
[HTML][HTML] Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease
X Zhang, Y Zhou, R Ma - Journal of Diabetes and its Complications, 2022 - Elsevier
Diabetic kidney disease (DKD) is one of the main causes of end-stage renal disease
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …
Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in db/db mice and KKAy mice compared with valsartan treatment
Although renin-angiotensin blockade has shown beneficial outcomes in patients with
diabetes, renal injury progresses in most of these patients. Therefore, there remains a need …
diabetes, renal injury progresses in most of these patients. Therefore, there remains a need …
Renoprotective effects of small interfering RNA targeting liver angiotensinogen in experimental chronic kidney disease
DM Bovée, L Ren, E Uijl… - …, 2021 - Am Heart Assoc
Small interfering RNA (siRNA) targeting liver angiotensinogen (AGT) lowers blood pressure,
but its effectiveness in hypertensive chronic kidney disease is unknown. Considering that …
but its effectiveness in hypertensive chronic kidney disease is unknown. Considering that …
Potential of renin-angiotensin-aldosterone system modulations in diabetic kidney disease: old players to new hope!
Due to a tragic increase in the incidences of diabetes globally, diabetic kidney disease
(DKD) has emerged as one of the leading causes of end-stage renal diseases (ESRD) …
(DKD) has emerged as one of the leading causes of end-stage renal diseases (ESRD) …
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
EO Cruz‐López, L Ren, E Uijl… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Small interfering RNA (siRNA) targeting liver angiotensinogen
lowers blood pressure, but its effects in hypertensive diabetes are unknown. Experimental …
lowers blood pressure, but its effects in hypertensive diabetes are unknown. Experimental …