Sialidases in vertebrates: a family of enzymes tailored for several cell functions
E Monti, E Bonten, A D'Azzo, R Bresciani… - Advances in …, 2010 - Elsevier
A bstract This review summarizes the recent research development on vertebrate sialidase
biology. Sialic acid-containing compounds play important roles in many physiological …
biology. Sialic acid-containing compounds play important roles in many physiological …
Ganglioside GM3 and its biological functions
NV Prokazova, NN Samovilova, EV Gracheva… - Biochemistry …, 2009 - Springer
Ganglioside GM3 and its biological functions | Biochemistry (Moscow) Skip to main content
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Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease
V Seyrantepe, SA Demir, ZK Timur… - Experimental …, 2018 - Elsevier
Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the
gene that encodes for the α subunit of lysosomal β-hexosaminidase A (HEXA), which …
gene that encodes for the α subunit of lysosomal β-hexosaminidase A (HEXA), which …
Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis
The mammalian neuraminidase (NEU) enzymes are found in diverse cellular compartments.
Members of the family, such as NEU2 and NEU1, are cytosolic or lysosomal, while NEU3 …
Members of the family, such as NEU2 and NEU1, are cytosolic or lysosomal, while NEU3 …
[HTML][HTML] The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
DE van der Wal, AM Davis, M Mach, DC Marks - Haematologica, 2020 - ncbi.nlm.nih.gov
Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα
(GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage …
(GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage …
Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: hints for the design of selective NEU3 inhibitors
S Magesh, T Suzuki, T Miyagi, H Ishida… - Journal of Molecular …, 2006 - Elsevier
Four types of human sialidases have been cloned and characterized at the molecular level.
They are classified according to their major intracellular location as intralysomal (NEU1) …
They are classified according to their major intracellular location as intralysomal (NEU1) …
Visualization of sialidase activity in Mammalian tissues and cancer detection with a novel fluorescent sialidase substrate
A Minami, T Otsubo, D Ieno, K Ikeda, H Kanazawa… - PLoS …, 2014 - journals.plos.org
Sialidase removes sialic acid from sialoglycoconjugates and plays crucial roles in many
physiological and pathological processes. Various human cancers express an abnormally …
physiological and pathological processes. Various human cancers express an abnormally …
Inhibitors of the human neuraminidase enzymes
CW Cairo - MedChemComm, 2014 - pubs.rsc.org
The human neuraminidase enzymes (hNEU) are a family of four isoenzymes that hydrolyze
sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play …
sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play …
Substrate recognition of the membrane-associated sialidase NEU3 requires a hydrophobic aglycone
MS Sandbhor, N Soya, A Albohy, RB Zheng… - Biochemistry, 2011 - ACS Publications
The human neuraminidases (NEU) consist of a family of four isoforms (NEU1–NEU4).
Members of this enzyme family are proposed to have important roles in health and disease …
Members of this enzyme family are proposed to have important roles in health and disease …
Profiling of N‐glycosylation gene expression in CHO cell fed‐batch cultures
DCF Wong, NSC Wong, JSY Goh… - Biotechnology and …, 2010 - Wiley Online Library
One of the goals of recombinant glycoprotein production is to achieve consistent
glycosylation. Although many studies have examined the changes in the glycosylation …
glycosylation. Although many studies have examined the changes in the glycosylation …