RNA m6A methylation regulators in endometrial cancer

S Shen, J Guo, N Lv, Q Chen… - … Journal of Oncology, 2022 - spandidos-publications.com
As one of the three major malignant tumor types of the female reproductive system,
endometrial cancer (EC) is the most prevalent gynecologic cancer in developed countries. In …

Crosstalk between m6A RNA methylation and miRNA biogenesis in cancer: An unholy nexus

PJ Jayasree, S Dutta, P Karemore, P Khandelia - Molecular Biotechnology, 2023 - Springer
Abstract N6-methyladenosine (m6A) is one of the most prevalent internal reversible
chemical modification of RNAs in eukaryotes, which has attracted widespread attention …

Long-term MNNG exposure promotes gastric carcinogenesis by activating METTL3/m6A/miR1184 axis-mediated epithelial-mesenchymal transition

T Liu, Y Feng, R Wang, S Yang, Y Ge, T Zhang… - Science of The Total …, 2024 - Elsevier
As the representative item of environmental chemical carcinogen, MNNG was closely
associated with the onset of Gastric cancer (GC), while the underlying mechanisms remain …

METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma

K Shi, R Sa, L Dou, Y Wu, Z Dong, X Fu, H Yu - Clinical Epigenetics, 2023 - Springer
Background Multiple genetic and epigenetic regulatory mechanisms play a vital role in
tumorigenesis and development. Understanding the interplay between different epigenetic …

Gene signature of m6A RNA regulators in diagnosis, prognosis, treatment, and immune microenvironment for cervical cancer

S Wang, B Ding, S Wang, W Yan, Q Xia, D Meng… - Scientific Reports, 2022 - nature.com
Continuing studies imply that m6A RNA modification is involved in the development of
cervical cancer (CC), but lack strong support on recurrence and diagnosis prediction. In this …

Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification

X Sun, H Wang, X Pu, Y Wu, X Yuan, X Wang… - Cancer Gene …, 2024 - nature.com
Abstract N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the
most common epigenetic modification in mammalian mRNA. M6A modifications play a …

Small Molecules that Regulate the N6-Methyladenosine RNA Modification as Potential Anti-Cancer Agents

NJ Harrahill, MK Hadden - European Journal of Medicinal Chemistry, 2024 - Elsevier
Epitranscriptomics, the field of post-translational RNA modifications, is a burgeoning domain
of research that has recently received significant attention for its role in multiple diseases …

NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung …

K Shi, Y Chen, R Liu, X Fu, H Guo, T Gao… - Cancer Cell …, 2024 - Springer
Background Multiple genetic and epigenetic regulatory mechanisms are crucial in the
development and tumorigenesis process. Transcriptional regulation often involves intricate …

[HTML][HTML] The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model

K Ostrowska, AA Rawłuszko-Wieczorek… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Background RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer
in the progression of N 6-methyladenosine (m 6 A) modification. This epigenetic feature …

Critical roles and clinical perspectives of RNA methylation in cancer

G Li, Q Yao, P Liu, H Zhang, Y Liu, S Li, Y Shi, Z Li… - MedComm, 2024 - Wiley Online Library
RNA modification, especially RNA methylation, is a critical posttranscriptional process
influencing cellular functions and disease progression, accounting for over 60% of all RNA …