Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Abstract Background The One Health concept considers the interconnectivity, interactions
and interdependence of humans, animals and the environment. Humans, animals and other …

Beyond providing evolutionary advantages, venoms offer unique research tools, as they
were developed to target functionally important proteins and pathways. As a key pain …

Centipede venoms have emerged as a rich source of novel bioactive compounds. However,
most centipede species are commonly considered too small for venom extraction and …

Centipedes are among the most ancient groups of venomous predatory arthropods. Extant
species belong to five orders, but our understanding of the composition and evolution of …

Neuropeptides are signalling molecules mainly secreted from neurons that act as
neurotransmitters or peptide hormones to affect physiological processes and modulate …

Difficult drug targets are becoming the normal course of business in drug discovery,
sometimes due to large interacting surfaces or only small differences in selectivity regions …

Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts
a significant burden on health authorities worldwide. Currently, management of chronic pain …

Epilepsy is characterised by spontaneous recurrent seizures that are caused by an
imbalance between neuronal excitability and inhibition. Since ion channels play …

The millions of extant arthropod species are testament to their evolutionary success that can
at least partially be attributed to venom usage, which evolved independently in at least 19 …