Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

The production of harmful free radicals (H-FRs), especially those with oxygen or nitrogen
atoms, depends on both internal and environmental causes. The negative effects of H-FRs …

Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Chemodynamic therapy (CDT) is a newly emerged, minimally invasive treatment with high
selectivity, few side effects, and good prospects for clinical application. However, CDT does …

There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the
production of testosterone. Increasing evidence shows that melatonin benefits the …

Obesity is a chronic condition whose management is a critical challenge for physicians. The
scientific community has increased its focus on the molecular mechanisms involved in …

Using mass spectrometry‐based targeted metabolomics, we aimed to determine the pattern
of cardiac metabolic reprogramming and energetics in doxorubicin‐induced heart failure …

Doxorubicin (DOX) is a widely used and potent anticancer agent, but DOX dose-
dependently induced cardiotoxicity greatly limits its use in clinic. Pterostilbene, a natural …

The incidence of cardiovascular disorders is one of the most concerns among people who
underwent cancer therapy. The heart side effects of cancer therapy may occur during …