Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …
AMPK activation: a therapeutic target for type 2 diabetes?
KA Coughlan, RJ Valentine… - … syndrome and obesity …, 2014 - Taylor & Francis
Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …
Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications
K Ziqubu, PV Dludla, E Joubert, CJF Muller… - Pharmacological …, 2020 - Elsevier
Isoorientin is a natural C-glucosyl flavone that is generating a lot of interest due to its
multiple pharmacological activities. Increasing experimental data have shown that the robust …
multiple pharmacological activities. Increasing experimental data have shown that the robust …
Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance by modulating PI3K/AKT and AMPK pathways
SE Mazibuko-Mbeje, PV Dludla, C Roux… - International journal of …, 2019 - mdpi.com
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …
[HTML][HTML] A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes
Dimethyl sulfoxide (DMSO) is an effective solvent and cytoprotectant agent that can induce
diverse actions in experimental settings, ranging from metabolic stress to cytotoxic effects …
diverse actions in experimental settings, ranging from metabolic stress to cytotoxic effects …
Aspalathin from rooibos (Aspalathus linearis): a bioactive C-glucosyl dihydrochalcone with potential to target the metabolic syndrome
Aspalathin is a C-glucosyl dihydrochalcone that is abundantly present in Aspalathus
linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally …
linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally …
Sarcopenia in a type 2 diabetic state: reviewing literature on the pathological consequences of oxidative stress and inflammation beyond the neutralizing effect of …
N Muvhulawa, SE Mazibuko-Mbeje, D Ndwandwe… - Life Sciences, 2023 - Elsevier
Sarcopenia remains one of the major pathological features of type 2 diabetes (T2D),
especially in older individuals. This condition describes gradual loss of muscle mass …
especially in older individuals. This condition describes gradual loss of muscle mass …
Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …
Aspalathin, a dihydrochalcone C‐glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis
Scope Energy deprivation in the myocardium is associated with impaired heart function. This
study aims to investigate if aspalathin (ASP) can ameliorate hyperglycemic‐induced shift in …
study aims to investigate if aspalathin (ASP) can ameliorate hyperglycemic‐induced shift in …
Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome
CJF Muller, CJ Malherbe, N Chellan… - Critical Reviews in …, 2018 - Taylor & Francis
Risk factors of type 2 diabetes mellitus (T2D) and cardiovascular disease (CVD) cluster
together and are termed the metabolic syndrome. Key factors driving the metabolic …
together and are termed the metabolic syndrome. Key factors driving the metabolic …