Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells
SE Mazibuko-Mbeje, SXH Mthembu, PV Dludla… - Toxicology in Vitro, 2021 - Elsevier
Insulin resistance and mitochondrial dysfunction are characteristic features of type 2
diabetes mellitus. However, a causal relationship between insulin resistance and …
diabetes mellitus. However, a causal relationship between insulin resistance and …
Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration
Aspalathin is a rooibos flavonoid with established blood glucose lowering properties,
however, its efficacy to moderate complications associated with hepatic insulin resistance is …
however, its efficacy to moderate complications associated with hepatic insulin resistance is …
Benzyl isothiocyanate ameliorates high-fat diet-induced hyperglycemia by enhancing Nrf2-dependent antioxidant defense-mediated IRS-1/AKT/TBC1D1 signaling …
Obesity caused lipotoxicity, which results in insulin resistance. We studied whether benzyl
isothiocyanate (BITC) improved insulin resistance in muscle. BITC was studied in vivo in …
isothiocyanate (BITC) improved insulin resistance in muscle. BITC was studied in vivo in …
Aspalathin-rich green rooibos extract lowers LDL-cholesterol and oxidative status in high-fat diet-induced diabetic vervet monkeys
P Orlando, N Chellan, J Louw, L Tiano, I Cirilli… - Molecules, 2019 - mdpi.com
Type 2 diabetic patients possess a two to four-fold-increased risk for cardiovascular
diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction …
diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction …
Rutin attenuates tumor necrosis factor-α-induced inflammation and initiates fat browning in 3T3-L1 adipocytes: Potential therapeutic implications for anti-obesity …
N Muvhulawa, PV Dludla, SXH Mthembu… - South African Journal of …, 2023 - Elsevier
Obesity is linked with a pathological state of inflammation, leading to the development and
aggravation of metabolic diseases. The adipose tissue secretes adipokines and cytokines …
aggravation of metabolic diseases. The adipose tissue secretes adipokines and cytokines …
Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato (Ipomoea batatas) Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in …
TB Ayeleso, K Ramachela, E Mukwevho - Molecules, 2018 - mdpi.com
Edible plants such as sweet potato are sources of natural antioxidants that can be exploited
in the management and treatment of insulin resistance. This present study investigated the …
in the management and treatment of insulin resistance. This present study investigated the …
Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus
F Francini, GR Schinella, JL Ríos - Mini reviews in medicinal …, 2019 - ingentaconnect.com
Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia,
whose development can be prevented or delayed by using therapeutic agents and …
whose development can be prevented or delayed by using therapeutic agents and …
Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice
C Wang, Z Chen, S Li, Y Zhang, S Jia, J Li, Y Chi… - Diabetes, 2014 - Am Diabetes Assoc
ATP synthase β subunit (ATPSβ) had been previously shown to play an important role in
controlling ATP synthesis in pancreatic β-cells. This study aimed to investigate the role of …
controlling ATP synthesis in pancreatic β-cells. This study aimed to investigate the role of …
Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative …
It remains essential to decipher some of the pathological mechanisms that link obesity with
deteriorating human health. Insulin resistance, due to enhanced free fatty acid substrate …
deteriorating human health. Insulin resistance, due to enhanced free fatty acid substrate …
Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on …
O Patel, C Muller, E Joubert, J Louw, B Rosenkranz… - Molecules, 2016 - mdpi.com
Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical
for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the …
for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the …