Rooibos (Aspalathus linearis), widely known as a herbal tea, is endemic to the Cape
Floristic Region of South Africa (SA). It produces a wide range of phenolic compounds that …

Multiple post-receptor intracellular alterations such as impaired glucose transfer, glucose
phosphorylation, decreased glucose oxidation, and glycogen production contribute to …

The insulin receptor (IR) is a 320 kDa membrane receptor tyrosine kinase mediating the
pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates …

Dexmedetomidine (Dex) is widely used in the sedation in intensive care units and as an
anesthetic adjunct. Considering the anti-inflammatory and antioxidant properties of Dex, we …

Traditional rooibos iced teas prepared using fermented rooibos extract contain a low
concentration of the unique antioxidant, aspalathin, which also has anti-diabetic properties …

Background Testicular insulin signalling is altered in diabetic (DM) males. While unravelling
the mechanism through which DM exert these detrimental effects, studies have shown the …

Rooibos is consumed worldwide and its use considered safe. It contains scavengers of free
radicals and is so is deemed to be a liver protector. Nevertheless, hepatic toxicity exists even …

Prebiotic fibre represents a promising and efficacious treatment to manage pre-diabetes,
acting via complementary pathways involving the gut microbiome and viscosity-related …

Impaired mitochondrial function and loss of cellular proteostasis control are key hallmarks of
aging and are implicated in the development of neurodegenerative diseases. A common …

Cardiovascular disease (CVD) is a leading cause of worldwide deaths. A number of risk
factors for cardiovascular disease as well as type 2 diabetes and stroke present as the …