Tobacco smoking is a major determinant of preventable morbidity and mortality worldwide.
More than a billion people smoke, and without major increases in cessation, at least half will …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Obesity is a heterogeneous disease that affects almost one-third of the global population. A
clear association has been established between obesity and cardiovascular disease (CVD) …

The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and
potentially permanent side effect of cancer treatment. For the management of OIPN, accurate …

Developmental and epileptic encephalopathies (DEEs) are among the most challenging of
all epilepsies to manage, given the exceedingly frequent and often severe seizure types …

Dravet Syndrome (DS) is a developmental epileptic encephalopathy characterized by drug-
resistant seizures and other clinical features, including intellectual disability and behavioral …

Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe and potentially permanent
side effect of cancer treatment affecting the majority of oxaliplatin-treated patients, mostly …