The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV)
initiated a quarter century of laboratory and epidemiological studies that demonstrated their …

The capsid protein L2 plays major roles in both papillomavirus assembly and the infectious
process. While L1 forms the majority of the capsid and can self-assemble into empty virus …

Using a murine challenge model, we previously determined that human papillomavirus
(HPV) pseudovirions initially bind preferentially to the cervicovaginal basement membrane …

The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral
shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and …

Although the papillomavirus structural proteins, L1 and L2, can spontaneously coassemble
to form virus-like particles, currently available methods for production of L1/L2 particles …

Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the
second most common cause of death from cancer among women worldwide. This Review …

An estimated 5% of human cancers are caused by human papillomavirus (HPV) infections,
and most of these cancers are of the cervix. Two prophylactic HPV vaccines that target the …

Papillomaviruses are a family of nonenveloped DNA tumor viruses. Some sexually
transmitted human papillomavirus (HPV) types, including HPV type 16 (HPV16), cause …

Background: Studies in animal models have shown that systemic immunization with a
papillomavirus virus-like particle (VLP) vaccine composed of L1, a major structural viral …

Over the past several decades, knowledge of the biology and epidemiology of human
papillomavirus (HPV) infection has increased tremendously. However, there are still many …