[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
[HTML][HTML] DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
[HTML][HTML] Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
GD Guler, Y Ning, CJ Ku, T Phillips, E McCarthy… - Nature …, 2020 - nature.com
Pancreatic cancer is often detected late, when curative therapies are no longer possible.
Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5 …
Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5 …
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children …
Maternal smoking during pregnancy has been found to influence newborn DNA methylation
in genes involved in fundamental developmental processes. It is pertinent to understand the …
in genes involved in fundamental developmental processes. It is pertinent to understand the …
[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing
The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …
scene can be of substantial value in forensic investigations. Aging can be complex and is …
[HTML][HTML] Reconfiguration of DNA methylation in aging
M Zampieri, F Ciccarone, R Calabrese… - Mechanisms of ageing …, 2015 - Elsevier
A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …
[HTML][HTML] DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies
X Gao, M Jia, Y Zhang, LP Breitling, H Brenner - Clinical epigenetics, 2015 - Springer
Active smoking is a major preventable public health problem and an established critical
factor for epigenetic modification. In this systematic review, we identified 17 studies …
factor for epigenetic modification. In this systematic review, we identified 17 studies …
[HTML][HTML] DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …