Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

In the brain, acetylcholine (ACh) is regarded as one of the major neurotransmitters. During
the advancement of Alzheimer's disease (AD) cholinergic deficits occur and this can lead to …

Cholinergic markers, neuropeptides, and amines and their metabolites were sampled from
identical specimens across 10 neocortical regions in a large sample of Alzheimer's disease …

Significant progress has been made over the last decade in delineating the
neuropathological and neurochemical changes in the brains of patients with Alzheimer's …

The cloning of APP and genetic analysis of families with Alzheimer's disease were both
reported in 1987 and much present work on the disease is based upon the foundations laid …

Heme oxygenase-1 is an important enzyme that degrades heme, a pro-oxidant, leading to
the formation of antioxidant molecules. In this study we demonstrate by …

The cholinergic hypothesis of Alzheimer's disease originally postulated a connection
between some of the cognitive impaiments of this disorder, particularly memory, and a …

Excitatory amino acids (EAA) such as glutamate and aspartate are major transmitters of the
cerebral cortex and hippocampus and EAA mechanisms appear to play a role in learning …

Cerebral cortex samples from patients with Alzheimer's disease and from rats after
experimental cholinergic denervation of the cerebral cortex exhibited reductions in the …

Publisher Summary The chapter discusses the Alzheimer disease. It is described as a fatal
degenerative dementing disorder with initial mild memory impairment that progresses …