The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …

The lysis of bacterial hosts by double-strand DNA bacteriophages, once thought to reflect
merely the accumulation of sufficient lysozyme activity during the infection cycle, has been …

Microbial ecology is currently undergoing a revolution, with repercussions spreading
throughout microbiology, ecology and ecosystem science. The rapid accumulation of …

Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Life history theory accounts for variations in many traits involved in the reproduction and
survival of living organisms, by determining the constraints leading to trade-offs among …

The effect of lysis timing on bacteriophage (phage) fitness has received little theoretical or
experimental attention. Previously, the impact of lysis timing on phage fitness was studied …

Theory predicts that selection for pathogen virulence and horizontal transmission is highest
at the onset of an epidemic but decreases thereafter, as the epidemic depletes the pool of …

The first step of bacteriophage (phage) infection is the attachment of the phage virion onto a
susceptible host cell. This adsorption process is usually described by mass-action kinetics …

During λ infections, the holin S105 accumulates harmlessly in the membrane until, at an
allele-specific time, suddenly triggering to form irregular holes of unprecedented size (> 300 …