Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system
and the central nervous system that support neuronal survival, synaptic plasticity, and …

Signaling mediated by brain-derived neurotrophic factor (BDNF), which is supported by the
postsynaptic scaffolding protein PSD-95, has antidepressant effects. Conversely, clinical …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a significant role in the
survival and development of neurons, being involved in several diseases such as …

Postpartum depression (PPD) is a severe psychiatric disorder with devastating
consequences on child development and mother's health. Dysregulation of glutamatergic …

Chronic stress is an environmental risk factor for depression and causes neuronal atrophy in
the prefrontal cortex (PFC) and other brain regions. It is still unclear about the molecular …

Goal‐directed action refers to selecting behaviors based on the expectation that they will be
reinforced with desirable outcomes. It is typically conceptualized as opposing habit‐based …

Restricted repetitive behaviors (RRB) are one of two diagnostic criteria for autism spectrum
disorder and common in other neurodevelopmental and psychiatric disorders. The term …

Stress can either promote or impair learning and memory. Such opposing effects depend on
whether synapses persist or decay after learning. Maintenance of new synapses formed at …

Background Prenatal stress (PS) can increase the risk of nervous, endocrine and metabolic
diseases and induce depression in offspring. Paeoniflorin (PA) is an amorphous glucoside …