Fixed combination for the treatment of dyslipidaemia

N Ferri, M Ruscica, RD Santos, A Corsini - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review It is clear from epidemiological studies that patients at high and
very-high risk of atherosclerotic cardiovascular diseases (ASCVD) risk do not reach lipid …

A new approach of statin therapy in carotid atherosclerosis: Targeting indices of plaque vulnerability on the top of lipid-lowering. A narrative review

NPE Kadoglou, E Khattab, N Velidakis… - Polish Heart …, 2022 - journals.viamedica.pl
Novel imaging techniques and biomarkers have emerged as surrogate markers of carotid
plaque vulnerability. In parallel, statin administration in patients with established carotid …

Effect of high-dose statin therapy on coagulation factors: lowering of factor XI as a modifier of fibrin clot properties in coronary artery disease

K Stępień, J Siudut, M Konieczyńska, K Nowak… - Vascular …, 2023 - Elsevier
Background Multiple pleiotropic effects of statins include antithrombotic properties with
formation of looser fibrin networks more susceptible to lysis. Recently, rosuvastatin 20 mg/d …

Green electrochemical methodology for simultaneous determination of atorvastatin and ezetimibe: Application to biological matrices

SA Atty, AM Abdel-raoof, FA Fouad… - Sustainable Chemistry …, 2023 - Elsevier
In this context, we report the first electrochemical sensing platform for the simultaneous
quantitation of two antihyperlipidemic drugs, namely, atorvastatin (ATR) and ezetimibe …

Low-density lipoprotein cholesterol-lowering drugs: a narrative review

N Ferri, M Ruscica, S Fazio, A Corsini - Journal of Clinical Medicine, 2024 - mdpi.com
The modern history of cholesterol-lowering drugs started in 1972 when Dr. Akira Endo
identified an active compound (compactin) that inhibited cholesterol biosynthesis from the …

Implication of lipids in calcified aortic valve pathogenesis: why did statins fail?

MJ Nsaibia, A Devendran, E Goubaa, J Bouitbir… - Journal of Clinical …, 2022 - mdpi.com
Calcific Aortic Valve Disease (CAVD) is a fibrocalcific disease. Lipoproteins and oxidized
phospholipids play a substantial role in CAVD; the level of Lp (a) has been shown to …

Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction at one-year follow-up

D Drwiła, P Rostoff, G Gajos, J Nessler… - Polish Heart …, 2021 - journals.viamedica.pl
Background: The triglyceride-glucose index (TyG index) is a novel metabolic marker initially
used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor …

Towards personalized therapy of aortic stenosis

P Mazur, M Kopytek, M Ząbczyk, A Undas… - Journal of Personalized …, 2021 - mdpi.com
Calcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease
in adults with no available pharmacological treatment to inhibit the disease progression to …

Aortic valvular stenosis: Novel therapeutic strategies

J Natorska, M Kopytek, A Undas - European Journal of Clinical …, 2021 - Wiley Online Library
Background Aortic stenosis (AS) prevalence is estimated to reach 4.5 million cases
worldwide by the year 2030. AS is a progressive disease without a pharmacological …

Therapy with high-dose statins reduces soluble P-selectin: The impact on plasma fibrin clot properties

J Siudut, J Pudło, M Konieczyńska, M Polak… - International Journal of …, 2023 - Elsevier
Objective Studies on the effect of statins on platelets in patients with coronary artery disease
(CAD) yielded inconsistent results. We sought to investigate whether high-dose statin …