Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Neuronal plasticity in the brain is greatly enhanced during critical periods early in life and
was long thought to be rather limited thereafter. Studies in primary sensory areas of the …

Abstract INVADING GLIOMA CELLS seem to follow distinct anatomic structures within the
central nervous system. Tumor cell dissemination may occur along structures, such as the …

Chondroitin sulfate proteoglycans (CS-PGs) expressed by reactive astrocytes may
contribute to the axon growth-inhibitory environment of the injured CNS. The specific …

Publisher Summary This chapter focuses on the changes in the expression of the axon
growth-inhibitory chondroitin sulphate proteoglycans (CSPGs). CSPGs represent a varied …

Proteoglycans comprise a part of the extracellular matrix that participates in the molecular
events that regulate cell adhesion, migration and proliferation. Their structural diversity and …

What determines whether cells remain in one place, retaining their associations with their
neighbors, or dissociate from these associations and move elsewhere? And, if they move …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …