[HTML][HTML] The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …
A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease …
Introduction The search for drugs to treat Alzheimer's disease (AD) has failed to yield
effective therapies. Here we report the first genome‐wide search for biomarkers associated …
effective therapies. Here we report the first genome‐wide search for biomarkers associated …
At the crossing of ER stress and MAMs: a key role of sigma-1 receptor?
B Delprat, L Crouzier, TP Su, T Maurice - Calcium Signaling, 2020 - Springer
Calcium exchanges and homeostasis are finely regulated between cellular organelles and
in response to physiological signals. Besides ionophores, including voltage-gated Ca 2+ …
in response to physiological signals. Besides ionophores, including voltage-gated Ca 2+ …
[HTML][HTML] Sigma-1 receptor-modulated neuroinflammation in neurological diseases
J Jia, J Cheng, C Wang, X Zhen - Frontiers in cellular neuroscience, 2018 - frontiersin.org
A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
C Johannessen Landmark, H Potschka, S Auvin… - …, 2021 - Wiley Online Library
Developmental and epileptic encephalopathies (DEEs) are among the most challenging of
all epilepsies to manage, given the exceedingly frequent and often severe seizure types …
all epilepsies to manage, given the exceedingly frequent and often severe seizure types …
Characterization of 3 PET tracers for quantification of mitochondrial and synaptic function in healthy human brain: 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J
A Mansur, EA Rabiner, RA Comley… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Mitochondrial complex 1 is involved in maintaining brain bioenergetics; σ-1 receptor
responds to neuronal stress; and synaptic vesicle protein 2A reflects synaptic integrity …
responds to neuronal stress; and synaptic vesicle protein 2A reflects synaptic integrity …
[HTML][HTML] Therapeutic strategies targeting mitochondrial calcium signaling: a new hope for neurological diseases?
Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …
[HTML][HTML] The sigma receptors in Alzheimer's disease: New potential targets for diagnosis and therapy
T Wang, H Jia - International Journal of Molecular Sciences, 2023 - mdpi.com
Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …
[HTML][HTML] The Sigma-1 receptor is an ER-localized type II membrane protein
The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in cellular
homeostasis in normal physiology and in disease. Especially in neurodegenerative …
homeostasis in normal physiology and in disease. Especially in neurodegenerative …
[HTML][HTML] Neurotrophic factor-based pharmacological approaches in neurological disorders
M Alfonsetti, M d'Angelo, V Castelli - Neural regeneration …, 2023 - journals.lww.com
Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …
and processes leading to cognitive decline. This process represents the major risk factor for …