Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …

Introduction The search for drugs to treat Alzheimer's disease (AD) has failed to yield
effective therapies. Here we report the first genome‐wide search for biomarkers associated …

Calcium exchanges and homeostasis are finely regulated between cellular organelles and
in response to physiological signals. Besides ionophores, including voltage-gated Ca 2+ …

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …

Developmental and epileptic encephalopathies (DEEs) are among the most challenging of
all epilepsies to manage, given the exceedingly frequent and often severe seizure types …

Mitochondrial complex 1 is involved in maintaining brain bioenergetics; σ-1 receptor
responds to neuronal stress; and synaptic vesicle protein 2A reflects synaptic integrity …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …

The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in cellular
homeostasis in normal physiology and in disease. Especially in neurodegenerative …

Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …