Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and
butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer's disease …

Parkinson's disease (PD) is a progressive neurodegenerative disease with limited treatment
options. Therefore, the identification of therapeutic targets is urgently needed. Previous …

Despite the high contagion and mortality rates that have accompanied the coronavirus
disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly …

Mitochondria are essential for neuronal survival and function, and mitochondrial dysfunction
plays a critical role in the pathological development of Parkinson's disease (PD) …

Sigma receptors (σRs) are considered to be a significant and valid target for developing new
medications to address several diseases. Their potential involvement in numerous central …

Abstract The sigma-1 (σ 1) receptor is a chaperone protein located on the mitochondria-
associated membrane of the endoplasmic reticulum, while the sigma-2 receptor (σ 2) is an …

There is a need to disentangle the etiological puzzle of age-related neurodegenerative
diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that …

Abstract Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and
psychiatric disorders and are a novel target for the treatment of such disorders. Sig-1R …

Background: Transient receptor potential ankyrin 1 (TRPA1) activation is implicated in
neuropathic pain-like symptoms. However, whether TRPA1 is solely implicated in pain …

The sigma receptor system has been classified into two distinct subtypes, sigma 1 (σ1R) and
sigma 2 (σ2R). Sigma 1 receptors (σ1Rs) are involved in many neurodegenerative diseases …