Abstract Sigma 1 receptor (Sig1R), a pluripotent modulator of cell survival, is neuroprotective
in models of retinal degeneration when activated by the high-affinity, high-specificity ligand …

The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane
protein implicated in a variety of central nervous system disorders and whose agonists have …

Familial Dysautonomia (FD) is an autosomal recessive congenital neuropathy that results
from a point mutation at the 5'splice site of intron 20 in the IKBKAP gene. This mutation …

Abstract The sigma-1 and sigma-2 (σ 1 and σ 2) receptors are found in high concentrations
in the brain, and their altered expression leads to a variety of neuropsychiatric disorders. 3 …

The human brain is an extraordinarily complex organ responsible for all aspects of cognition
and control. Billions of neurons form connections with thousands of other neurons, resulting …

Abstract Purpose Sigma-1 receptor (Sig-1R), a chaperone that resides at the mitochondrion-
associated endoplasmic reticulum (ER) membrane, is an ER stress biomarker. It is thought …

Multiple Sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of
the central nervous system (CNS). Current management strategies suppress or modulate …

Childhood ataxia with central nervous system hypomyelination/vanishing white matter
(CACH/VWM) disease is an autosomal recessive disorder characterized by progressive …

Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …

Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic
Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we …