Alzheimer's disease (AD) was suffered by 30-35 million patients worldwide and predicted to
increase to 400% within 30 years in Indonesia. One of the accepted therapeutics for AD is …

Sigma-1 receptor (Sigma1R; SIGMAR1), an integral membrane protein of the endoplasmic
reticulum and nuclear envelope, has a hydrophobic drug-binding pocket that binds with high …

Аннотация Специфическое связывание лиганда сигма-1 рецепторов (Sigma1R)[3 H](+)-
пентазоцина в Р2 и Р3 фракциях гомогенатов головного мозга определяли у …

На фенотипической модели расстройств аутистического спектра-мышах линии BALB/c-
показано, что афобазол в дозе 10 мг/кг уменьшает когнитивную ригидность. Афобазол …

Membrane contact sites (MCS) circumvent the topological constraints of functional coupling
between different membrane-bound organelles by providing a means of communication and …

Memantine, an N-methyl-D-aspartate receptor (NMDAR) antagonist is FDA approved for the
treatment of moderate to severe Alzheimer disease. The efficacy is believed to stem from its …

AD, also known as senile dementia, is a neurodegenerative disease characterized by latent
onset and progressive cognitive impairment. The main manifestations are memory and …

Neuroinflammation is an intricate process of the brain that naturally protects it from
pathogens, foreign bodies, or cellular debris. While initially protective, prolonged …

The first sigma receptor was discovered in 1976 but was erroneously considered another
subtype of opioid receptor. It was later recognized as a protein chaperone with the …