Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and
developmentally plastic mesenchymal cells. All cells in the heart arise from one or more …

Cardiac fibroblasts help maintain the normal architecture of the healthy heart and are
responsible for scar formation and the healing response to pathological insults. Various …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …

The embryonic epicardium, originating from the proepicardial organ (PEO), provides a
source of multipotent progenitors for cardiac lineages, including pericytes, fibroblasts, and …

The cellular complexity and scale of the early liver have constrained analyses examining its
emergence during organogenesis. To circumvent these issues, we analyzed 45,334 single …

Development requires the careful orchestration of several biological events in order to
create any structure and, eventually, to build an entire organism. On the other hand, the fate …

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …

The HAND2 transcriptional regulator controls cardiac development, and we uncover
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …