Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

Genetics ultimately defines an individual, yet the phenotype of an adult is extensively
determined by the sequence of lifelong exposures, termed the exposome. The redox theory …

Local drug delivery has become an effective method for disease therapy in fine organs
including ears, eyes, and noses. However, the multiple anatomical and physiological …

With the recent approvals for the application of monoclonal antibodies that target the well-
characterized immune checkpoints, immune therapy shows great potential against both …

The Food and Drug Administration–approved drug sirolimus, which inhibits mechanistic
target of rapamycin (mTOR), is the leading candidate for targeting aging in rodents and …

Several studies identified hearing loss as a risk factor for aging-related processes, including
neurodegenerative diseases, as dementia and age-related hearing loss (ARHL). Although …

Isoforms of a gene may contribute to diverse biological functions. In the cochlea, the
repertoire of alternative isoforms remains unexplored. We integrated single-cell short-read …

A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in
aging and age‐related diseases. However, the mechanism of PIN1 in age‐related hearing …

Fragile X syndrome (FXS) is characterized by hypersensitivity to sensory stimuli, including
environmental sounds. We compared the auditory brainstem response (ABR) recorded in …

In the developing auditory system, spontaneous activity generated in the cochleae
propagates into the central nervous system to promote circuit formation. The effects of …