Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

Adjunctive treatments for the prevention of chemotherapy-and radiotherapy-induced mucositis

M Thomsen, L Vitetta - Integrative Cancer Therapies, 2018 - journals.sagepub.com
Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation,
dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose …

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers

TA Lawrie, JT Green, M Beresford… - Cochrane Database …, 2018 - cochranelibrary.com
Background An increasing number of people survive cancer but a significant proportion
have gastrointestinal side effects as a result of radiotherapy (RT), which impairs their quality …

Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells

P Wang, N Kljavin, TTT Nguyen, EE Storm, B Marsh… - Cell Stem Cell, 2023 - cell.com
The intestinal epithelium has high intrinsic turnover rate, and the precise renewal of the
epithelium is dependent on the microenvironment. The intestine is innervated by a dense …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Alterations of the gut microbiome composition and lipid metabolic profile in radiation enteritis

Y Li, H Yan, Y Zhang, Q Li, L Yu, Q Li, C Liu… - Frontiers in cellular …, 2020 - frontiersin.org
Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy.
Although studies have shown the changes of this disease at clinical, pathological and other …

A review on curability of cancers: more efforts for novel therapeutic options are needed

S Wang, Y Liu, Y Feng, J Zhang, J Swinnen, Y Li, Y Ni - Cancers, 2019 - mdpi.com
Cancer remains a major cause of death globally. Given its relapsing and fatal features,
curing cancer seems to be something hardly possible for the majority of patients. In view of …

The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000 …

I Aziz, MF Peerally, JH Barnes, V Kandasamy… - Gut, 2017 - gut.bmj.com
Background Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease
(CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor …

Radiation enteritis: Diagnostic and therapeutic issues

L Loge, C Florescu, A Alves, B Menahem - Journal of visceral surgery, 2020 - Elsevier
Abdominal pelvic radiation therapy can induce acute or chronic lesions in the small bowel
wall, called radiation enteritis. Treatment of acute radiation enteritis is essentially …

Treatment-related complications of systemic therapy and radiotherapy

V Jairam, V Lee, HS Park, CR Thomas… - JAMA …, 2019 - jamanetwork.com
Importance Systemic therapy and radiotherapy can be associated with acute complications
that may require emergent care. However, there are limited data characterizing …