What to do about pertussis vaccines? Linking what we know about pertussis vaccine effectiveness, immunology and disease transmission to create a better vaccine

S Bolotin, ET Harvill, NS Crowcroft - Pathogens and disease, 2015 - academic.oup.com
Pertussis (whooping cough) is a respiratory disease caused by the bacterium Bordetella
pertussis. Despite the implementation of immunization programs and high vaccine coverage …

Whole-cell and acellular pertussis vaccine: reflections on efficacy

M Alghounaim, Z Alsaffar, A Alfraij… - Medical Principles and …, 2022 - karger.com
Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis.
Although most cases occur in developing countries, it is considered endemic globally. The …

IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: effect of vaccine antigen content

LH Hendrikx, GAM Berbers, RH Veenhoven… - Vaccine, 2009 - Elsevier
Since whooping cough is reemerging in the Netherlands from 1996 onwards, several
changes in the national immunization program have been implemented regarding the …

Antibody persistence to diphtheria toxoid, tetanus toxoid, Bordetella pertussis antigens, and Haemophilus influenzae type b following primary and first booster with …

N Wanlapakorn, N Sarawanangkoor… - Human Vaccines & …, 2024 - Taylor & Francis
Thailand has incorporated the whole-cell (wP) pertussis vaccine into the expanded program
on immunization since 1977 and has offered the acellular pertussis (aP) vaccine as an …

Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells

ES Hovingh, M van Gent, HJ Hamstra, M Demkes… - PloS one, 2017 - journals.plos.org
Vaccines against pertussis have been available for more than 60 years. Nonetheless, this
highly contagious disease is reemerging even in countries with high vaccination coverage …

What is wrong with pertussis vaccine immunity? Inducing and recalling vaccine-specific immunity

CS Eberhardt, CA Siegrist - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
The high incidence of pertussis in vaccinated adolescents suggests the failing of immune
memory. We argue that acellular pertussis vaccines generate memory cells that are …

Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age

SA Halperin, D Scheifele, L Barreto, C Pim… - The Pediatric …, 1999 - journals.lww.com
Study design. In a double blind, multicenter study, 366 healthy children were randomly
allocated to receive a single injection of a 5-component acellular or a whole cell pertussis …

Pertussis serology: assessment of IgG anti‐PT ELISA for replacement of the CHO cell assay

T Dalby, C Sørensen, JW Petersen, KA Krogfelt - Apmis, 2010 - Wiley Online Library
Dalby T, Sørensen C, Petersen JW, Krogfelt KA. Pertussis serology: assessment of IgG anti‐
PT ELISA for replacement of the CHO cell assay. APMIS 2010; 118: 968–72. Two types of …

Effectiveness of a single dose of acellular pertussis vaccine to prevent pertussis in children primed with pertussis whole cell vaccine

G De Serres, R Shadmani, N Boulianne, B Duval… - Vaccine, 2001 - Elsevier
We estimated the protection given by one booster dose of acellular pertussis vaccine (aP)
given at 18 months or before school entry to children already primed with whole cell vaccine …

Diphtheria-Tetanus-Acellular Pertussis Vaccine Adsorbed (Triacelluvax™; DTaP3-CB) A Review of its Use in the Prevention of Bordetella pertussis Infection

AJ Matheson, KL Goa - Pediatric Drugs, 2000 - Springer
Abstract Abstract DTaP3-CB (Triacelluvax™) 1. is an acellular pertussis (aP) vaccine
containing 3 antigens from purified Bordetella pertussis bacteria combined with diphtheria …