Hormonal influences in migraine—interactions of oestrogen, oxytocin and CGRP

DN Krause, K Warfvinge, KA Haanes… - Nature Reviews …, 2021 - nature.com
Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery

Z Song, HE Albers - Frontiers in neuroendocrinology, 2018 - Elsevier
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social
cognition/social behavior and in the periphery to influence a variety of physiological …

Current understanding of trigeminal ganglion structure and function in headache

K Messlinger, AF Russo - Cephalalgia, 2019 - journals.sagepub.com
Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

K Messlinger, LK Balcziak, AF Russo - Journal of neural transmission, 2020 - Springer
The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of
sensory neurons with their peripheral and central processes. Most neurons are surrounded …

Interplay between oxytocin and sensory systems in the orchestration of socio-emotional behaviors

V Grinevich, R Stoop - Neuron, 2018 - cell.com
The neuropeptide oxytocin (OT) attracts the interest of neuroscientists, psychologists, and
psychiatrists due to its capacity to modulate emotional and social behavior. Although much …

Pathophysiology of post-traumatic trigeminal neuropathic pain

OA Korczeniewska, D Kohli, R Benoliel… - Biomolecules, 2022 - mdpi.com
Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

H Nishimura, M Yoshimura, M Shimizu… - Communications …, 2022 - nature.com
Oxytocin is involved in pain transmission, although the detailed mechanism is not fully
understood. Here, we generate a transgenic rat line that expresses human muscarinic …

Oxytocin relieves neuropathic pain through GABA release and presynaptic TRPV1 inhibition in spinal cord

W Sun, Q Zhou, X Ba, X Feng, X Hu… - Frontiers in molecular …, 2018 - frontiersin.org
Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic
nucleus of the hypothalamus. In addition to its role in uterine contraction, OT plays an …

Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …

Oxytocin and migraine headache

A Tzabazis, S Kori, J Mechanic, J Miller… - … : The Journal of …, 2017 - Wiley Online Library
This article reviews material presented at the 2016 Scottsdale Headache Symposium. This
presentation provided scientific results and rationale for the use of intranasal oxytocin for the …