Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in
development, regulating numerous processes including apoptosis, receptor signalling …

To form a diffusible interface large enough to conduct respiratory gas exchange with the
circulation, the lung endoderm undergoes extensive branching morphogenesis and …

Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

Morphogenesis of the mouse lung involves reciprocal interactions between the epithelial
endoderm and the surrounding mesenchyme, leading to an invariant early pattern of …

NKX2. 1 is a homeodomain transcriptional factor expressed in thyroid, lung, and parts of the
brain. We demonstrate that septation of the anterior foregut along the dorsoventral axis, into …

Fibroblast growth factor (FGF) signaling is required for normal epithelial branching in the
respiratory system of several species. Recent studies have shown that FGF-10 may be a key …

Foxa1 and Foxa2 are closely related family members of the Foxa group of transcription
factors that are coexpressed in subsets of respiratory epithelial cells throughout lung …

The airways are lined by several distinct epithelial cells that play unique roles in pulmonary
homeostasis; however, the mechanisms controlling their differentiation in health and …

▪ Abstract There is increasing evidence suggesting that formation of the tracheobronchial
tree and alveoli results from heterogeneity of the epithelial-mesenchymal interactions along …

Side population (SP) cells are a rare subset of cells found in various tissues that are highly
enriched for stem cell activity. SP cells can be isolated by dual-wavelength flow cytometry …