Circulating tumor cells and circulating tumor DNA: challenges and opportunities on the path to clinical utility

M Ignatiadis, M Lee, SS Jeffrey - Clinical Cancer Research, 2015 - AACR
Recent technological advances have enabled the detection and detailed characterization of
circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from …

Circulating tumor cell isolation, culture, and downstream molecular analysis

S Sharma, R Zhuang, M Long, M Pavlovic, Y Kang… - Biotechnology …, 2018 - Elsevier
Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a
promising prognostic significance in cancer detection. Performing functional and molecular …

An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

ML De Angelis, F Francescangeli, C Nicolazzo… - Journal of Experimental …, 2022 - Springer
Abstract Background Circulating tumor cells (CTCs) are responsible for the metastatic
dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. CTCs rarity …

[HTML][HTML] Circulating tumor cells in hepatocellular carcinoma: single-cell based analysis, preclinical models, and clinical applications

Q Zhang, Y Rong, K Yi, L Huang, M Chen, F Wang - Theranostics, 2020 - ncbi.nlm.nih.gov
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors and
metastatic lesions and provide significant information about tumor progression and …

Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer

LE Cortés-Hernández, Z Eslami-S… - Molecular aspects of …, 2020 - Elsevier
Metastasis is the main cause of death in patients with cancer. The molecular mechanisms
underlying the different metastasis steps are not yet fully known, partly because most studies …

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy

S Maheswaran, DA Haber - Cancer research, 2015 - AACR
With increasing application of targeted therapies and the development of acquired
resistance, much attention is being focused on developing in vitro and in vivo patient …

Circulating tumor microemboli: Progress in molecular understanding and enrichment technologies

M Umer, R Vaidyanathan, NT Nguyen… - Biotechnology …, 2018 - Elsevier
Circulating tumor cells (CTCs) and their clusters, also known as circulating tumor
microemboli (CTM), have emerged as valuable tool that can provide mechanistic insights …

Ex vivo expansion and drug sensitivity profiling of circulating tumor cells from patients with small cell lung cancer

HL Lee, JF Chiou, PY Wang, LS Lu, CN Shen, HL Hsu… - Cancers, 2020 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) is an overly aggressive cancer
characterized by rapid growth, early metastatic spread, and consequently reducing overall …

Short-term ex vivo culture of CTCs from advance breast cancer patients: clinical implications

N Carmona-Ule, M González-Conde, C Abuín… - Cancers, 2021 - mdpi.com
Simple Summary Circulating tumor cells (CTCs) are responsible for metastasis, they
represent tumor biology and have also predictive value for therapy monitoring and …

[HTML][HTML] Liquid biopsy in pancreatic cancer: the beginning of a new era

DK Yadav, X Bai, RK Yadav, A Singh, G Li, T Ma… - Oncotarget, 2018 - ncbi.nlm.nih.gov
With dismal survival rate pancreatic cancer remains one of the most aggressive and
devastating malignancy. Predominantly, due to the absence of a dependable methodology …