The potential importance of drug-drug interaction (DDIs) is increasing as polypharmacy
becomes more and more prevalent. In vitro data cannot directly predict clinical DDIs, but …

The kinetic and dynamic interactions of 5 mg zolpidem and 50 mg trazodone with 500 mg
clarithromycin (4 doses given over 32 h) were investigated in a 5‐way double crossover …

The article presents three clinical cases which illustrate how familiarity with principles of
pharmacokinetics and pharmacodynamics can facilitate optimal understanding and …

Understanding and documentation of drug–drug interactions (DDIs) are an important
component of drug development, and of clinical therapeutics. Because clinical DDI studies …

Methods This section should specify the site or sites at which the study was conducted and
the institutional review board responsible for oversight. The paper should explicitly state that …

Drug interactions are an important consideration in clinical practice, especially among
populations where chronic therapy with multiple medications is common. As most countries …

Innovations in drug development have led to the introduction of many chemical entities in
clinical practice over the past 60 years. This innovation coupled with the increasing use of …

Drug metabolism is the process of chemical conversion of a drug to a metabolite preparatory
to its elimination from the body. Four general categories of drug metabolic reactions occur …

Opioid analgesics are frequently used in critically ill patients for the treatment of moderate to
severe pain from either a comorbid or an acute condition. There is a potential for clinically …

Biotransformation is important in the drug discovery process because several aspects of the
clinical profile of a drug candidate depend on the process of biotransformation. Clearance of …