Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Increasing energy expenditure through activation of endogenous brown adipose tissue
(BAT) is a potential approach to treat obesity and diabetes. The class of β3-adrenergic …

Metabolic syndrome (MetS), today a major global public health problem, is a cluster of
clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension …

Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …

The incidence of the metabolic syndrome has reached epidemic levels in the Western world.
With respect to the energy balance, most attention has been given to reducing energy (food) …

Atherosclerosis, for which hyperlipidemia is a major risk factor, is the leading cause of
morbidity and mortality in Western society, and new therapeutic strategies are highly …

Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from
where it is released by axonal varicosities throughout the brain via volume transmission. A …

Major depressive disorder (MDD) which is supposed to result from a complex interaction of
genetic and epigenetic, environmental and developmental factors is one of the most …