The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II
JD Hayes, DJ Pulford - Critical reviews in biochemistry and …, 1995 - Taylor & Francis
The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …
Concise review of the glutathione S-transferase and their significance to toxicology.
DL Eaton, TK Bammler - Toxicological sciences, 1999 - search.ebscohost.com
The article discusses the major features of the glutathione S-transferases (GST), a multi-
gene family of enzymes involved in the detoxification or activation of a wide variety of …
gene family of enzymes involved in the detoxification or activation of a wide variety of …
[HTML][HTML] Regulation of JNK signaling by GSTp
V Adler, Z Yin, SY Fuchs, M Benezra, L Rosario… - The EMBO …, 1999 - embopress.org
Studies of low basal Jun N‐terminal kinase (JNK) activity in non‐stressed cells led us to
identify a JNK inhibitor that was purified and identified as glutathione S‐transferase Pi …
identify a JNK inhibitor that was purified and identified as glutathione S‐transferase Pi …
[HTML][HTML] Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants …
F Ali-Osman, O Akande, G Antoun, JX Mao… - Journal of biological …, 1997 - ASBMB
We report the isolation of three full-length cDNAs corresponding to the mRNAs of closely
related glutathione S-transferase (GST) Pi genes, designated hGSTP1* A, hGSTP1* B, and …
related glutathione S-transferase (GST) Pi genes, designated hGSTP1* A, hGSTP1* B, and …
Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution.
MA Watson, RK Stewart, GB Smith, TE Massey… - …, 1998 - academic.oup.com
The association between glutathione S-transferase (GST) activity as measured by 1-chloro-
2, 4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human …
2, 4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human …
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
LW Harries, MJ Stubbins, D Forman… - …, 1997 - academic.oup.com
Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus,
which differ by a single base pair (AG) substitution at nucleotide 313 of the GSTP1 cDNA …
which differ by a single base pair (AG) substitution at nucleotide 313 of the GSTP1 cDNA …
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
K Berhane, M Widersten, Å Engström… - Proceedings of the …, 1994 - National Acad Sciences
Radiation and chemical reactions that give rise to free radicals cause the formation of highly
cytotoxic base propenals, degradation products of DNA. Human glutathione transferases …
cytotoxic base propenals, degradation products of DNA. Human glutathione transferases …
Glutathione transferases and cancer
S Tsuchida, K Sato - Critical reviews in biochemistry and molecular …, 1992 - Taylor & Francis
The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …
[HTML][HTML] Role of glutathione S-transferases in protection against lipid peroxidation: overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide …
Y Yang, JZ Cheng, SS Singhal, M Saini… - Journal of Biological …, 2001 - ASBMB
The physiological significance of the selenium-independent glutathione peroxidase (GPx)
activity of glutathione S-transferases (GSTs), associated with the major Alpha class …
activity of glutathione S-transferases (GSTs), associated with the major Alpha class …
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
CJ Henderson, AG Smith, J Ure… - Proceedings of the …, 1998 - National Acad Sciences
The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …