Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical
setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …