This review provides an overview of the synaptic dysfunction of neuronal circuits and the
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …

Sleep is an essential component of development. Developmental sleep disruption (DSD)
impacts brain maturation and has been associated with significant consequences on socio …

Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD).
Importantly, a clinically relevant connection exists between inflammation and metabolic …

Background Abnormalities of lipid metabolism contributing to the autism spectrum disorder
(ASD) pathogenesis have been suggested, but the mechanisms are not fully understood …

Alterations in the balance between excitation and inhibition, especially in the brain's critical
developmental periods, are considered an integral part of the pathophysiology of autism …

Neurons maintain stable levels of excitability using homeostatic synaptic scaling, which
adjusts the strength of a neuron's postsynaptic inputs to compensate for extended changes …

Assembly of transcriptomes encoding unique neuronal identities requires selective
accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded …

The hippocampus participates in spatial navigation and behavioral processes, displays
molecular plasticity in response to environmental challenges, and can play a role in …

Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare
variants contribute significantly to disease risk. Although many genes have been associated …

The study of diseases of the central nervous system (CNS) at the molecular level is
challenging because of the complexity of neural circuits and the huge number of specialized …